A Systematic Review and Meta-Analysis of microRNA Profiling Studies in Chronic Kidney Diseases

Garmaa, Gantsetseg and Bunduc, Stefania and Kói, Tamás and Hegyi, Péter and Csupor, Dezső and Ganbat, Dariimaa and Dembrovszky, Fanni and Meznerics, Fanni Adél and Nasirzadeh, Ailar and Barbagallo, Cristina and Kökény, Gábor (2024) A Systematic Review and Meta-Analysis of microRNA Profiling Studies in Chronic Kidney Diseases. Non-Coding RNA, 10 (3). p. 30. ISSN 2311-553X

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Abstract

Chronic kidney disease (CKD) represents an increasing health burden. Evidence suggests the importance of miRNA in diagnosing CKD, yet the reports are inconsistent. This study aimed to determine novel miRNA biomarkers and potential therapeutic targets from hypothesis-free miRNA profiling studies in human and murine CKDs. Comprehensive literature searches were conducted on five databases. Subgroup analyses of kidney diseases, sample types, disease stages, and species were conducted. A total of 38 human and 12 murine eligible studies were analyzed using Robust Rank Aggregation (RRA) and vote-counting analyses. Gene set enrichment analyses of miRNA signatures in each kidney disease were conducted using DIANA-miRPath v4.0 and MIENTURNET. As a result, top target genes, Gene Ontology terms, the interaction network between miRNA and target genes, and molecular pathways in each kidney disease were identified. According to vote-counting analysis, 145 miRNAs were dysregulated in human kidney diseases, and 32 were dysregulated in murine CKD models. By RRA, miR-26a-5p was significantly reduced in the kidney tissue of Lupus nephritis (LN), while miR-107 was decreased in LN patients’ blood samples. In both species, epithelial-mesenchymal transition, Notch, mTOR signaling, apoptosis, G2/M checkpoint, and hypoxia were the most enriched pathways. These miRNA signatures and their target genes must be validated in large patient cohort studies.

Item Type: Article
Subjects: Pustakas > Multidisciplinary
Depositing User: Unnamed user with email support@pustakas.com
Date Deposited: 10 May 2024 07:56
Last Modified: 10 May 2024 07:56
URI: http://archive.pcbmb.org/id/eprint/1999

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