The Future of Prodrugs Design

When knowledge fails to provide answers to important questions such as how to improve the
bioavailability of vital medications, “Imagination is more important than knowledge,” as Albert Einstein
once said. Ingenuity in the design of effective prodrugs has been lacking in quantity and quality. The
reasons behind the low quality of ingenuity could be related to the fact that medicinal chemists have
expertise in organic and organometalic chemistry not in biochemistry and biology. On the other hand,
pharmaceutical chemists, biologists and biochemists do not have the expertise to make sophisticated
chemical devices. Therefore, in order for a prodrug strategy to work, a team consisting of all this
expertise is necessary.