Cross-Sectional and Longitudinal Associations between Skin Autofluorescence and Tubular Injury Defined by Urinary Excretion of Liver-Type Fatty Acid-Binding Protein in People with Type 2 Diabetes

Yamagami, Hiroki and Hara, Tomoyo and Yasui, Saya and Hosoki, Minae and Hori, Taiki and Kaneko, Yousuke and Mitsui, Yukari and Kurahashi, Kiyoe and Harada, Takeshi and Yoshida, Sumiko and Nakamura, Shingen and Otoda, Toshiki and Yuasa, Tomoyuki and Kuroda, Akio and Endo, Itsuro and Matsuhisa, Munehide and Abe, Masahiro and Aihara, Ken-ichi (2023) Cross-Sectional and Longitudinal Associations between Skin Autofluorescence and Tubular Injury Defined by Urinary Excretion of Liver-Type Fatty Acid-Binding Protein in People with Type 2 Diabetes. Biomedicines, 11 (11). p. 3020. ISSN 2227-9059

[thumbnail of biomedicines-11-03020.pdf] Text
biomedicines-11-03020.pdf - Published Version

Download (1MB)

Abstract

It has previously been unclear whether the accumulation of advanced glycation end products, which can be measured using skin autofluorescence (SAF), has a significant role in diabetic kidney disease (DKD), including glomerular injury and tubular injury. This study was therefore carried out to determine whether SAF correlates with the progression of DKD in people with type 2 diabetes (T2D). In 350 Japanese people with T2D, SAF values were measured using an AGE Reader®, and both urine albumin-to-creatinine ratio (uACR), as a biomarker of glomerular injury, and urine liver-type fatty acid-binding protein (uLFABP)-to-creatinine ratio (uL-FABPCR), as a biomarker of tubular injury, were estimated as indices of the severity of DKD. Significant associations of SAF with uACR (p < 0.01), log-transformed uACR (p < 0.001), uL-FABPCR (p < 0.001), and log-transformed uL-FABPCR (p < 0.001) were found through a simple linear regression analysis. Although SAF was positively associated with increasing uL-FABPCR (p < 0.05) and increasing log-transformed uL-FABPCR (p < 0.05), SAF had no association with increasing uACR or log-transformed uACR after adjusting for clinical confounding factors. In addition, the annual change in SAF showed a significant positive correlation with annual change in uL-FABPCR regardless of confounding factors (p = 0.026). In conclusion, SAF is positively correlated with uL-FABP but not with uACR in people with T2D. Thus, there is a possibility that SAF can serve as a novel predictor for the development of diabetic tubular injury.

Item Type: Article
Subjects: Pustakas > Medical Science
Depositing User: Unnamed user with email support@pustakas.com
Date Deposited: 11 Nov 2023 07:19
Last Modified: 11 Nov 2023 07:19
URI: http://archive.pcbmb.org/id/eprint/1482

Actions (login required)

View Item
View Item