Critical Study: In vivo Anti-arthritic Activity of Ethanolic Extract of Elaeocarpus serratus L.

The anti-arthritic effect of oral administration of ethanolic extract of leaf and seed of Elaeocarpus
serratus was evaluated using Freund’s adjuvant arthritis model in Wistar rats. The acute toxicity
studies were carried out according to the OECD, 423 guidelines. Arthritis was induced by injecting
0.1ml of 1% Freund’s complete adjuvant into the subplantar region in the right hind paw. The oral
administrated with indomethacin (10 mg/ kg/day p.o.) daily for 15 days which served as the standard
reference group. The ethanolic extracts of leaf and seed of E. serratus at the doses of 200 and 400
mg/kg/day p.o., respectively daily for 15days. The increase in joint diameter was measured daily
starting from day 1, by using vernier calipers. Fresh blood samples were treated with various
biochemical parameters like SOD, CAT, GPx and GST was significantly reduced in the animals
treated with the ethanolic plant extracts. The lipid peroxidase was also significantly decreased in the
experimental rats. The results of the present study support the traditional use of this plant and it can
be used as anti-arthritic drug.