EFFECT OF Carica papaya LEAF SUSPENSION ON CARBOPLATIN INDUCED BLOOD CELLS TOXICITY IN MICE

Thrombocytopaenia is defined as persistent decrease in the number of blood platelets that may be associated with hemorrhagic tenderness. There are no effective methods to treat thrombocytopenia once it occurs. Transfusions, growth factor injections and bone marrow transplant have their limitations. So there is increased need for research of drugs that could prevent and treat thrombocytopenia. The objective the study to determine the effect of different doses of male and female papaya leaf juice on prevention of carboplatin induced thrombocytopenia in mice The Carica papaya leaf suspension was studied for its activity to prevent chemotherapy induced thrombocytopenia in mice. The results were compared using student t-test for individual samples. The activity of papaya leaf suspension was found to prevent thrombocytopenia was evaluated by measuring the blood platelet count daily from day1 to day17. Palm oil is used as a control as a study conducted and was showed there was no any significant difference0 in the thrombocyte count between nonnal saline and palm oil. The above findings suggested that Carica papaya leaf suspension significantly prevents the thrombocytopenia induced by chemotherapy mice.