Recent Development and Validation of a Dissolution Method for Lamotrigine Tablets by UPLC

The aim of the present work was to develop an accurate, precise, reproducible and economical development and validation of a dissolution method for lamotrigine tablets by UPLC. The UPLC method was carried out using buffer and acetonitrile 75:25%v/v. The flow rate 0.3 ml/min with UV detection at 310 nm. Column used was acquity UPLC BEH Shield RP18,2.1X50 mm. Assay percentage was found to be 100.8. The method was validated according to International Conference on Harmonization guidelines and successfully applied to marketed linearity was plotted from (100 µg/ml to 300 µg/ml) (r2 = 0.9979) Lamotrigene formulations. The method was found to be linear in the respectively. Satisfactory values of Percent relative standard deviation for the intra-day and inter-day precision studies indicated that method is precise. Literature review revealed enormous analytical methods were reported for the estimation of lamotrigene but there is no development and validation of a dissolution method for lamotrigine tablets by UPLC. The method was carefully assessed to guarantee the stability of the drug during the analysis time.